Yield & reconciliation
Track expected vs actual yields with clear loss accounting.
Summary
This calculator aligns with GMP expectations for yield tracking and material reconciliation described in ICH Q7 (Production and In-Process Controls) and EU GMP Part I Chapter 5.
Yield calculations compare actual output to theoretical or expected output. Reconciliation quantifies how much of the input material is accounted for through finished product and documented losses.
Use consistent units across inputs and document any reasons for yield loss or reconciliation differences to support investigations and batch record review.
Step-by-step: Calculate yield and reconciliation
- Confirm the theoretical or expected yield
Record the expected output for the batch based on the master formula and input quantities.
- Capture actual output and known losses
Document actual output and any accounted losses (sampling, rejects, transfers, or other planned losses).
- Calculate yield and reconciliation
Compare actual yield vs theoretical yield, and reconcile inputs against outputs and documented losses.
Yield inputs
Yield results
Provide theoretical and actual yield to calculate yield results.
Reconciliation inputs
Document all known losses to minimize unexplained variance.
Reconciliation results
Provide input, output, and loss values to calculate reconciliation.
Regulatory references
Read-only guidance aligned with major regulatory bodies.